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International Society For Minimally Invasive Cardiothoracic Surgery

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Esophageal Cancer Patients With Pathological Response
Ali Taghizadeh Kermani1, Reza Bagheri2, Hessam Taheri3, Mohsen Aliakbarian4, Ehsan Soltani5, Mona Joudi6
1Associate professor of oncology, surgical onchology research center, University of Medical Sciences, Mashhad, Iran, mashhad, Iran, Islamic Republic of, 2Professor of Thoracic Surgery, Lung Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Mashhad, Iran, Islamic Republic of, 3General practitioner, Lung Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, mashhad, Iran, Islamic Republic of, 4Associate professor of general surgery, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, mashhad, Iran, Islamic Republic of, 5Department of General Surgery, Acute Care Surgery Research Center, Mashhad University of Medical Sciences, Taleghani University Hospital, Mashhad, Iran, mashhad, Iran, Islamic Republic of, 6. Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, mashhad, Iran, Islamic Republic of

Objective: There have been a limited number of studies conducted to determine the pattern of relapse and survival in patients after neoadjuvant chemoradiotherapy and surgery for esophageal cancer. Our aim is to evaluate the survival and recurrence patterns in esophageal cancer patients with pathologic response to neoadjuvant chemoradiotherapy. Methods: This retrospective study was performed on 159 esophageal cancer patients receiving neoadjuvant chemoradiotherapy, a checklist of demographic and clinicaopathological variables was filled. Then, survival and recurrency patterns in esophageal cancer patients with complete and near complete pathologic response to neoadjuvant chemoradiotherapy were evaluated. Results: Among 159 of 1117 patients who had the inclusion criteria, 147 patients had complete pathological response and 12 had near complete pathological responses; In this study variables included age, type of tumor and tumor distance from the incisors which showed no significant difference, and among them, only sex and addiction were associated with the results. The overall survival and one year and three years disease free survival were 89.4 2.7%, 62.8% 5.7% and 93.2% 2. 2%, respectively. Conclusion:. It was also concluded that almost all patients with complete pathological responses had well differentiated cells and those with near complete responses had moderate differentiated cells; the most common type of recurrence was observed in systemic type of disease and the most common sites were lungs and liver. So that women and people with no history of addiction showed better responses to treatment and had higher levels of survival


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