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The Expression and Clinical Significance of Nodal Protain in Non-small Cell Lung Cancer
Jinyuan He, Jr., Li Yun, An Jun, Zheng Hongjie, Huang Shaohong, Zhang Junhang.
The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

OBJECTIVE: To detect and analyze the clonal significance of Nodal expression in human non-small cell lung cancer.
METHODS: Nodal protain was detected in 24 cases of squamous cell carcinoma and 70 cases of adenocarcinoma by immunohistochemical staining. Twenty cases of nornal lung tissue was used for control group,and analyze the correlation of Nodal expression between clinical factors such as histological type and differentiation,clinical stage,lymph node and distant metastasis .
RESULTS: Immunohistochemical staining showed Nodal positive expression rates of squamous cell lung cancer and lung adenocarcinoma were 33.3%(8/24) and 84.3% (59/70)respectively. Nodal expression was significantly higher than control group whose positive expression rates was 10.0%(p0.05). Nodal positive expression rate in high differentiation lung adenocarcinoma(76.7%) was lower than low differentiation(96.3%) (p<0.05). Nodal positive expression rates in clinical stage III-IV(94.7%) was higher than I-II(71.9%)(p<0.05). For patients with lymph node metastasis,Nodal positive expression rate was 92.8%,which was higher than without lymph node metastasis(71.4%)(p<0.05). For patients with and without oligometastasis,Nodal positive expression rates were 96.2% and 77.3% respectively,and there was statistical difference between them(p<0.05).
CONCLUSIONS: Nodal positive expression rate in lung adenocarcinoma was significantly higher than normal lung tissue,but there is no significant difference between squamous cell carcinoma and normal lung tissue. In lung adenocarcinoma,Nodal positive expression rate was detected higher in those patients with lower differentiation degree,advanced clinical stage,lymph node metastasis and distant metastasis.

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