A New Concept In The Development Of A Cardiac Assist Device Utilizing Nanotechnology
Mahmood Mirhoseini, Mary M. Cayton, Aria Manasherry.
Heart & Lung Institute of Wisconsin, Germantown, WI, USA.
BACKGROUNDHeart Failure is a major cause of death throughout the world. Current Assist devices have major complications including hemolysis, organ damage, and infection, and are similar in their basic design. Our goal was to develop a system which is effective and yet minimizes the causes of complications.
METHODS Advancements in nanotechnology allowed hexagonal electro -nano-magnets (10-9 ) to be embedded in a special polymer which is then wrapped around the failing heart chamber. There can be 1-4 polymer sacs. As the magnets repel and attract contraction occurs. All controls are external and controlled by radiofrequency. Contractions can be synchronized with the patients heart or controlled independently.Tubes and wires are not required so there is no blood interface or external connections.RESULTS Preliminary work indicates producing contraction by this method can generate a systolic pressure of up to 150mm mercury. Arrangement of the magnets can mimic the normal force vectors of contraction including the wringing or twisting mechanism of the normal heart. Nano particles produce a larger surface area in proportion to volume and mass, the device is efficient but estimated total weight is 4-500 grams.CONCLUSIONS This work is preliminary, but appears very promising. Elimination of the blood device interface and external connections with the body reduces the problems of hemolysis, organ failure, infection and other complications of current assist systems. This novel method to address the problems of heart failure may prove to be significant. Much further work and investigation is needed. LEGEND The vectors of force in normal contractility of the heart are indicated including the wringing motion as determined by unpublished data of other investigators.
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